Study Metrics
Total Sample
2048
Treatment Group
1812
Control Group
236
Covariates
16
PICO Comparisons
1
Quality Indicators
Transparency
High
DAG Usage
No
QBA Performed
No
Study Information
| First Author: | Softness |
| Publication Year: | 2022 |
| DOI: | https://doi.org/10.1016/j.urolonc.2021.12.015 |
| Preprint: | No preprint |
Institution & Funding
| Institution Type: | Academic |
| Institutions: | Beth Israel Deaconess Medical Center, Massachusetts General Hospital, University of Colorado |
| Funding: | Not declared |
Study Context
| Disease: | Bladder cancer |
| Disease Category: | Oncology |
| Data Type: | national_database |
| Number of Data Sources: | 1 |
| Geography: | US |
| Eligible Sample: | 2048.0 |
Analytical Methods
| Missing Data Method: | Complete case |
| Matching Method: | IPTW |
| Analysis Method: | Cox PH |
Quality Methods
Directed Acyclic Graph (DAG)
Not Used
Quantitative Bias Analysis (QBA)
Not Performed
Target Trial Information
| Target Trial Name: | SPARE |
| Registration Number: | ISRCTN61126465 |
| Target Trial DOI: | https://doi.org/10.1111/bju.13900 |
TTE vs RCT Comparisons
Detailed comparison between Target Trial Emulation results and corresponding Randomized Controlled Trial outcomes.
Overall survival
SPARE
HR
Efficacy
Population
patients aged 40 to 79 with cT2-3cN0cM0 urothelial carcinoma of the bladder
Intervention
Radical cystectomy (RC) with lymphadenectomy
Comparison
Trimodality therapy (TMT)
Outcome
Overall survival
RCT Result
3.05
95% CI: [0.92, 10.15]
vs
TTE Result
0.87
95% CI: [0.64, 1.19]
Concordance Assessment
Confidence Interval Overlap:
Yes
CIs overlap, suggesting concordance
CIs overlap, suggesting concordance
Direction Agreement:
Different Direction
Different conclusions
Different conclusions
Transparency Indicators
Protocol Registration
Available
Data Sharing
Not Available
Code Sharing
Not Available
Overall Transparency Score:
High Transparency - This study meets good transparency standards.
Conflicts & Funding
| Conflicts of Interest: | Declared: None |
| Funding Source: | Not declared |