Study Metrics
Total Sample
18222
Treatment Group
3462
Control Group
14760
Covariates
24
PICO Comparisons
2
Quality Indicators
Transparency
High
DAG Usage
No
QBA Performed
No
Study Information
| First Author: | Matthews |
| Publication Year: | 2022 |
| DOI: | https://doi.org/10.1093/aje/kwac098 |
| Preprint: | No preprint |
Institution & Funding
| Institution Type: | Academic |
| Institutions: | Karolinska Institutet, Harvard T.H. Chan School of Public Health, Örebro University Hospital, Uppsala University, Danderyd University Hospital-Karolinska Institutet |
| Funding: | Declared: Public, research institute, NGO |
| Funding Institutions: | This work was supported by a grant from the Swedish Research Council (2018-03028). A.A.M. received funds from the Strategic Research Program in Epidemiology at Karolinska Institutet, Forte (2020-00029), and Swedish Research Council (2021-02236). I.J.D. received funds from the Patient-Centered Outcomes Research Institute (PCORI; ME-1502-27794) during the conduct of the study. |
Study Context
| Disease: | Myocardial infarction |
| Disease Category: | Cardiology |
| Data Type: | Registry |
| Number of Data Sources: | 1 |
| Geography: | Sweden |
| Eligible Sample: | 18222.0 |
| Number of Treatments: | 2 |
Analytical Methods
| Missing Data Method: | Complete case |
| Matching Method: | Not defined |
| Analysis Method: | Cox PH |
| Estimand: | PP |
Quality Methods
Directed Acyclic Graph (DAG)
Not Used
Quantitative Bias Analysis (QBA)
Not Performed
Target Trial Information
| Target Trial Name: | TASTE |
| Registration Number: | NCT01093404 |
| Target Trial DOI: | https://doi.org/10.1056/NEJMoa1308789, https://doi.org/10.1056/NEJMoa1405707 |
TTE vs RCT Comparisons
Detailed comparison between Target Trial Emulation results and corresponding Randomized Controlled Trial outcomes.
Death
TASTE
RR
Efficacy
Population
Adults (≥18 years) with ST-elevation myocardial infarction (STEMI) requiring percutaneous coronary intervention (PCI)
Intervention
Thrombus aspiration followed by PCI
Comparison
PCI without thrombus aspiration
Outcome
Death
RCT Result
0.94
95% CI: [0.78, 1.15]
vs
TTE Result
1.09
95% CI: [0.96, 1.24]
Concordance Assessment
Confidence Interval Overlap:
Yes
CIs overlap, suggesting concordance
CIs overlap, suggesting concordance
Direction Agreement:
Different Direction
Different conclusions
Different conclusions
Myocardial infarction
TASTE
RR
Efficacy
Population
Adults (≥18 years) with ST-elevation myocardial infarction (STEMI) requiring percutaneous coronary intervention (PCI)
Intervention
Thrombus aspiration followed by PCI
Comparison
PCI without thrombus aspiration
Outcome
Myocardial infarction
RCT Result
0.97
95% CI: [0.73, 1.28]
vs
TTE Result
0.96
95% CI: [0.79, 1.17]
Concordance Assessment
Confidence Interval Overlap:
Yes
CIs overlap, suggesting concordance
CIs overlap, suggesting concordance
Direction Agreement:
Same Direction
Both point to similar conclusion
Both point to similar conclusion
Transparency Indicators
Protocol Registration
Available
Data Sharing
Not Available
Code Sharing
Available
Overall Transparency Score:
High Transparency - This study meets good transparency standards.
Conflicts & Funding
| Conflicts of Interest: | Declared: Financial |
| COI Institutions: | Sanofi Pasteur, Cytel, ProPublica |
| Funding Source: | Declared: Public, research institute, NGO |
| Funding Institutions: | This work was supported by a grant from the Swedish Research Council (2018-03028). A.A.M. received funds from the Strategic Research Program in Epidemiology at Karolinska Institutet, Forte (2020-00029), and Swedish Research Council (2021-02236). I.J.D. received funds from the Patient-Centered Outcomes Research Institute (PCORI; ME-1502-27794) during the conduct of the study. |