Study Metrics
Total Sample
67388
Treatment Group
58815
Control Group
8573
Covariates
19
PICO Comparisons
1
Quality Indicators
Transparency
High
DAG Usage
No
QBA Performed
No
Study Information
| First Author: | Bacic |
| Publication Year: | 2020 |
| DOI: | https://doi.org/10.1016/j.urology.2020.01.039 |
| Preprint: | No preprint |
Institution & Funding
| Institution Type: | Academic |
| Institutions: | Advance-CTR, Brown University, Rhode Island Hospital, Mayo Clinic, Warren Alpert Medical School of Brown University, Beth Israel Deaconess Medical Center |
| Funding: | Declared: Public |
| Funding Institutions: | The project described was supported by Institutional Development Award Number U54GM115677 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds Advance Clinical and Translational Research (Advance-CTR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
Study Context
| Disease: | Renal cell carcinoma |
| Disease Category: | Oncology |
| Data Type: | Other |
| Number of Data Sources: | 1 |
| Geography: | US |
| Eligible Sample: | 67388.0 |
| Number of Treatments: | 2 |
Analytical Methods
| Missing Data Method: | Complete case |
| Matching Method: | PS matching |
| Analysis Method: | Cox PH |
Quality Methods
Directed Acyclic Graph (DAG)
Not Used
Quantitative Bias Analysis (QBA)
Not Performed
Target Trial Information
| Target Trial Name: | EORTC 30881 |
| Target Trial DOI: | https://doi.org/10.1016/j.eururo.2008.09.052 |
TTE vs RCT Comparisons
Detailed comparison between Target Trial Emulation results and corresponding Randomized Controlled Trial outcomes.
Overall survival
EORTC 30881
HR
Efficacy
Population
patients with cT1-3cN0cM0 renal cell carcinoma
Intervention
radical nephrectomy with lymph node dissection
Comparison
radical nephrectomy alone
Outcome
Overall survival
RCT Result
1.02
95% CI: [0.80, 1.29]
vs
TTE Result
1.13
95% CI: [1.07, 1.20]
Concordance Assessment
Confidence Interval Overlap:
Yes
CIs overlap, suggesting concordance
CIs overlap, suggesting concordance
Direction Agreement:
Same Direction
Both point to similar conclusion
Both point to similar conclusion
Transparency Indicators
Protocol Registration
Available
Data Sharing
Not Available
Code Sharing
Not Available
Overall Transparency Score:
High Transparency - This study meets good transparency standards.
Conflicts & Funding
| Conflicts of Interest: | Declared: None |
| Funding Source: | Declared: Public |
| Funding Institutions: | The project described was supported by Institutional Development Award Number U54GM115677 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds Advance Clinical and Translational Research (Advance-CTR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |