About TTEdb
Learn about the Target Trial Emulation Database (TTEdb) - a comprehensive resource for TTE studies and their concordance with RCTs.
About TTEdb
TTEdb (Target Trial Emulation Database) is a comprehensive database examining concordance between target trial emulation studies and their corresponding randomized controlled trials.
This project represents a systematic meta-research effort to understand the validity and reliability of target trial emulation as a methodological approach. By comparing TTE results with their target RCTs, we aim to identify factors associated with better concordance and provide evidence-based recommendations for future TTE studies.
Database Metrics
Research Team
Comparative Efficacy Estimates Concordance Between Target Trial Emulations and Their Corresponding Target Trials: Protocol for a Living Meta-Epidemiological Study
This database is part of a comprehensive meta-epidemiological study examining the concordance between target trial emulations and their corresponding randomized controlled trials.
Ahmad Sofi-Mahmudi
Principal Investigator
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, L8S 4L8, Canada
Kristian Thorlund
Co-Investigator
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, L8S 4L8, Canada
Paul Arora
Co-Investigator
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada; Inka Health, Schwartz Reisman Innovation Campus, University of Toronto, Toronto, Ontario, M5G 0C6, Canada
Methodology
Study Design
TTEdb is based on a systematic review and meta-research study examining the concordance between target trial emulation studies and their corresponding randomized controlled trials.
Key Objectives:
- Primary: Assess consistency between TTE and RCT effect estimates
- Secondary: Identify factors associated with concordance
- Exploratory: Examine methodological quality patterns
- Practical: Develop recommendations for future TTE studies
Data Collection
Data was systematically extracted from published TTE studies following a pre-registered protocol.
Variables Collected:
- Study characteristics and publication details
- Transparency indicators (protocol, data, code availability)
- Methodological approaches (DAG usage, QBA, matching methods)
- PICO elements and effect estimates for both TTE and target RCTs
- Sample sizes and study quality metrics
Part of Xera DB Family
TTEdb is part of the Xera DB ecosystem, a collection of specialized research databases designed to advance evidence-based medicine and research methodology.
Funding & Support
This research is supported by funding from McMaster University and various research grants dedicated to advancing methodology in observational research and causal inference.
No industry funding or conflicts of interest related to the study outcomes.
License & Usage
TTEdb is made freely available for research and educational purposes under an open license.
Open Access
Data and code are available under Creative Commons and MIT licenses respectively. Please cite appropriately when using this resource.
Contact & Collaboration
Get in Touch
We welcome collaborations, feedback, and contributions to improve TTEdb. Whether you have questions about the methodology, want to contribute data, or are interested in collaborative research, please don't hesitate to reach out.
How to Contribute:
- Data Contribution: Share additional TTE studies for inclusion
- Methodology Feedback: Suggest improvements to data collection or analysis
- Technical Issues: Report bugs or suggest features
- Research Collaboration: Propose joint research projects
Contact Information
Primary Contact:
Ahmad Sofi-Mahmudi
Principal Investigator
Institution:
McMaster University
Department of Health Research Methods, Evidence, and Impact
How to Cite
Recommended Citation:
Sofi-Mahmudi, A., Thorlund, K., Dron, L., & Arora, P. (2024). TTEdb: Target Trial Emulation Database - A comprehensive database of target trial emulation studies and their concordance with randomized controlled trials. Retrieved from https://ttedb.xeradb.com
BibTeX:
@misc{sofimahmudi2024ttedb,
title={TTEdb: Target Trial Emulation Database},
author={Sofi-Mahmudi, Ahmad and Thorlund, Kristian and Dron, Louis and Arora, Paul},
year={2024},
url={https://ttedb.xeradb.com},
note={A comprehensive database of target trial emulation studies}
}Version Information:
- Version: 1.0.0
- Last Updated: July 2024
- DOI: Pending
- License: CC BY 4.0