Target Trial Emulation Database

A comprehensive database examining concordance between target trial emulations and their corresponding randomized controlled trials

Database Overview

31
TTE Studies
125
PICO Comparisons
10
Disease Categories
2019-2024
Publication Years

Recent Studies

Multiple conditions including cardiovascular outcomes, diabetes, antiplatelet agents, anticoagulants, hypertension, osteoporosis, kidney disease, heart failure, asthma, COPD, and prostate cancer | All areas

Claims data from US
High Transparency

Myocardial infarction | Cardiology

Registry data from Sweden
High Transparency

Multiple sclerosis | Neurology

Registry data from Italy, Australia, Turkey, Czech Republic, Kuwait, Switzerland, Spain, Lebanon, Canada
High Transparency

Psychosis | Psychology

Other data from US, Canada, Spain
High Transparency

COVID-19 | Infectious diseases

Ehr data from US
High Transparency DAG

Disease Categories

Oncology 11
Cardiology 7
Gastroenterology 2
Rheumatology 2
Opthalmology 1
Intensive care 1
Neurology 1
All areas 1
Psychology 1
Infectious diseases 1

About TTEdb

TTEdb is a comprehensive database examining the concordance between target trial emulation (TTE) studies and their corresponding randomized controlled trials (RCTs).

This database is part of a meta-research study investigating the validity and reliability of target trial emulation as a methodological approach. By systematically comparing TTE results with their target RCTs, we aim to identify factors associated with better concordance and provide evidence-based recommendations for future TTE studies.

Key Features
  • Comprehensive TTE study database
  • PICO-level comparisons with RCTs
  • Transparency indicators
  • Methodological quality assessment
Research Areas
  • Cardiovascular disease
  • Oncology
  • Infectious diseases
  • And many more...
Citation
Sofi-Mahmudi, A., Thorlund, K., Dron, L., & Arora, P. (2024). TTEdb: Target Trial Emulation Database. Retrieved from https://ttedb.xeradb.com